Download Antisense Therapeutics by Sudhir Agrawal PDF

By Sudhir Agrawal

Top researchers provide an authoritative survey and research of the most recent findings at the swift improvement of antisense oligonucleotides healing and their program in a variety of in vivo version structures. The book's high-profile members supply well timed bills in their cutting-edge options, discussing such subject matters because the synthesis and purification of oligonucleotides, their choice for a selected gene goal, diverse tools of management, and using quite a few mobilephone traces and mobile tradition structures. additionally they learn questions of mobile uptake, in vitro organic task, in vivo organic task, the pharmacology and pharmacokinetics of oligonucleotides, and the applying of oligonucleotides to the principal apprehensive process.

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Nat1 Acad Scz USA 91,4499-4503. 18 McCormick, F (1989) ras GTPase activating protem* stgnal transmitter and slgnal terminator Cell 56, 5-8 19 Hall, A. (1990) The cellular functions of small GTP-bmdmg protems Science 249,635-649. 20 Bokoch, G M. and Der, C J. , and Rapp, U R (1994) The ms and outs of Raf kmases TZBS 19,474-480 22 Btshop, J M (1987) The molecular genetics of cancer Science 235, 305-306 23 Bos, J. L (1989) ras Oncogenes in human cancer a revrew. Cancer Res 49, 46824689 24. , Smits, A , and Bos, J.

82,83). In this chapter, we have described early experiments that demonstrate that improved analogs are more stable and more potent in ammals. Although much remains to be learned, a great deal of progress has clearly been made in an area that 1sproving to be an important advance m therapeutics. References 10. , and Crooke, S (1993) Disposition of the 14C-labeled phosphorothtoate ohgonucleottde ISIS 2105 after intravenous admmlstratton to rats J Pharmacol Exp Ther 267, 1181-l 190. Cossum, P A, Truong, L , Owens, S.

And Yu, Z P (1991) Antisense inhibition of ras p21 expression that is sensitive to a point mutation Biochemrstry 30, 8283-8286. 33 Georges, R. , and Saison-Behmoaras, T (1994) Anttsense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell prohferatton and tumorigetuclty m nude mice. Proc Nat1 Acad Scr USA 91, 10,460-l 0,464 35. Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phosphohprds and activation of protein kinase C Science 258,607-614.

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