By Sudhir Agrawal
Top researchers provide an authoritative survey and research of the most recent findings at the swift improvement of antisense oligonucleotides healing and their program in a variety of in vivo version structures. The book's high-profile members supply well timed bills in their cutting-edge options, discussing such subject matters because the synthesis and purification of oligonucleotides, their choice for a selected gene goal, diverse tools of management, and using quite a few mobilephone traces and mobile tradition structures. additionally they learn questions of mobile uptake, in vitro organic task, in vivo organic task, the pharmacology and pharmacokinetics of oligonucleotides, and the applying of oligonucleotides to the principal apprehensive process.
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82,83). In this chapter, we have described early experiments that demonstrate that improved analogs are more stable and more potent in ammals. Although much remains to be learned, a great deal of progress has clearly been made in an area that 1sproving to be an important advance m therapeutics. References 10. , and Crooke, S (1993) Disposition of the 14C-labeled phosphorothtoate ohgonucleottde ISIS 2105 after intravenous admmlstratton to rats J Pharmacol Exp Ther 267, 1181-l 190. Cossum, P A, Truong, L , Owens, S.
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