By A. Surbone, F. Peccatori, N. Pavlidis
This booklet is written through specialists with scientific services on analysis, therapy, and follow-up of girls with melanoma while pregnant. It presents a complete evaluate of information and an summary of mental, moral, and social features. Chapters tackle the prognosis, therapy, and follow-up of ladies with strong or hematologic cancers. the protection of next being pregnant and the upkeep or enhancement of fertility in ladies present process melanoma remedy also are addressed.
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Extra resources for Cancer and Pregnancy (Recent Results in Cancer Research)
1980; Ortega 1977. 4 case reports of 2nd- and 3rd-trimester exposure Normal pregnancy outcome Sood et al. 2001; Mendez et al. 2003; GonzalezAngulo et al. 2004; Gadducci et al. 2004. D. Pereg, M. Lishner Paclitaxel 9 patients with acute leukemia exposed to No congenital malformation. regimens that contained vincristine (5 cases during 4 cases of IUGR 1st trimester) 1 case of severe pancytopenia 30 Drug Drug Description of study Outcome of pregnancy Methotrexate 20 patients with cancer or rheumatic diseases, with 7 cases developed a pattern very similar to the 1st-trimester exposure aminopterin syndrome (cranial dysostosis with delayed ossification, hypertelorism, wide nasal bridge micrognatia, and ear anomalies).
Teratog Carcinog Mutagen 13: 139–143 D. Pereg, M. Lishner Zuazu J, Julia A, Sierra J et al. (1991) Pregnancy outcome in hematologic malignancies. Cancer 67: 703–709. 4 Breast Cancer During Pregnancy: Epidemiology, Surgical Treatment, and Staging O. Gentilini Recent Results in Cancer Research, Vol. 1 Definition and Epidemiology Historically, pregnancy-associated breast cancer was defined as breast cancer diagnosed during pregnancy and within 1 year of delivery. The present chapter deals with the situation of coincident breast cancer and pregnancy, which represents the real challenge for physicians.
This was especially true regarding aminopterin, which is an antimetabolite that is no longer in use, and its administration during the first trimester has been associated with high risk for developing the aminopterin syndrome (cranial dysostosis with delayed ossification, hypertelorism, wide nasal bridge micrognatia, and ear anomalies) (Weizz et al. 2004). A very similar pattern of malformation has been described after first-trimester exposure to high-dose methotrexate (>10 mg/week). Furthermore, methotrexate, which is used as an abortifacient in the treatment of ectopic pregnancy, increases the risk for miscarriage when administered early in pregnancy.