Download Carcinogenicity of Inorganic Substances. Risks from by J H Duffus PDF

By J H Duffus

Specializes in the country of medical wisdom concerning the carcinogenicity of metals, their compounds and different inorganic components. It offers a precious advisor for chemists occupied with chance overview, future health and protection and toxicology

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Other experiments indicated a range of tumour probability between fibre types with a similar number of Stanton fibres. For example, two tremolite asbestos samples produced a 100% tumour probability, while a talc sample having a greater number of Stanton fibres produced no tumours (see Nolan and Langer, 1994 for a further discussion). 17 26 1 27 1 17 12 The correlation between the number of Stanton fibres and the tumour probability is variable. 5-fold higher incidence than the fibrous starting material using a crocidolite milled until approximately 99% of the fibres were 'isometric'.

The DNA is then more open to mutation. A typical attack is the well-known action of the anti-cancer drug cw-platin. The P t ion attacks the N(7) of guanine. There is an old saying that those agents which cure cancer can also cause cancer. It is based on the fact that curing cancer requires an attack on DNA (of a cancer cell), but cell chemistry being what it is means that there is a risk of mutagenesis or rearrangement of DNA of a normal cell as well as a chance of destruction of the DNA of a cancerous one.

Stimulates metallothionein synthesis and interferes with Cu , Zn metabolism C H 3 H g compounds are lipid-soluble 2+ Hg Pb Tl + Damage to the central nervous system; neuropsychiatric disorders Saturnism; injuries to the peripheral nervous system; disturbs haem synthesis and affects the kidneys Poisonous to nervous systems; enters cells via K channels + + + P b may replace C a with loss of functional (and structural) integrity. Replaces Z n in 5-aminolaevulinic acid dehydratase; reacts with sulfhydryl groups T l is similar to K and binds more tightly, including to N and S ligands 2+ 2+ 2+ + + 38 4 Bio-inorganic Chemistry and Cancer Conclusion There is an inevitable association of both DNA and inorganic elements with life and of life with the environment.

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