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Am J Hypertens 1997; 10: 1-8 [51] Latini R, Masson S, Anand I, Salio M, Hester A, Judd D, Barlera S, Maggioni AP, Tognoni G, Cohn JN: The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT. Eur Heart J 2004; 25: 292-9 30 Chronic Kidney Disease and Renal Transplantation [52] Siragy HM: Rationale for combining a direct renin inhibitor with other reninangiotensin system blockers. Focus on aliskiren and combinations. Cardiovasc Drugs Ther 2010; 25: 87-97 3 Parathyroid Hormone-Related Protein as a Mediator of Renal Damage: New Evidence from Experimental as well as Human Nephropathies Ricardo J.

Thus, the survival range in the ARI has not improved in recent years. , 1996). Depending on the intensity of and exposure time to the agent inducing the initial damage, ARI can progress to chronic renal disease - the evolution of which is an irreversible process characterized by the loss of nephrons and the development of fibrosis - and thus to ESRD (Chevalier, 2006; Remuzzi & Bertani, 1998). The study of the mechanisms implicated in renal fibrosis, the final pathway to different nephropathies which can progress to ESRD, is very interesting as it involves the search for, and evaluation of, agents with therapeutic applications.

J Hypertens 2011; 29: 207-16 [18] Marre M, Lievre M, Chatellier G, Mann JF, Passa P, Menard J: Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study). BMJ 2004; 328: 495 [19] Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P: The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes.

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